Endocrine Abstracts

The first patient with a catecholamine-secreting paraganglioma that was sucessfully resected was in 1926. Over the past 97 years, there has been a dramatic evolution in the clinical presentation, methods used to diagnose and localize, and germline genetic testing of paragangliomas (PGLs). When contrasted to adrenal pheochromocytoma, PGLs present the clinician with unique challenges, which include: 1) diverse location—they may be located anywhere from the tympanic membrane...

BackgroundBenign adrenocortical tumours are found in 3–5% of adults and can be non-functioning (NFAT) or associated with cortisol excess. The latter group divides into patients with clinically overt signs (adrenal Cushing’s syndrome, CS) and patients lacking CS signs (mild autonomous cortisol excess, MACE). The 1 mg-overnight dexamethasone suppression test (DST) further differentiates MACE into MACE-1 (possible MACE; post-DST cortisol 50–1...